(Oct 19) The Illinois Fighting Illini beat the Wisconsin Badgers as a 28.5 point home underdog.
(Oct 12) The Bowling Green Falcons beat the Toledo Rockets as a 26.5 point home underdog.
(Sep 14) The The Citadel Bulldogs beat the Georgia Tech Yellow Jackets as a 25.5 point road underdog.
(Aug 31) The Georgia State Panthers beat the Tennessee Volunteers as a 24.5 point road underdog.
(Oct 26) The Kansas State Wildcats beat the Oklahoma Sooners as a 23.5 point home underdog.
(Oct 19) The Vanderbilt Commodores beat the Missouri Tigers as a 21.0 point home underdog.
(Nov 23) The Florida International Golden Panthers beat the Miami Hurricanes as a 21.0 point home underdog.
(Oct 12) The South Carolina Gamecocks beat the Georgia Bulldogs as a 20.5 point road underdog.
(Sep 21) The San José State Spartans beat the Arkansas Razorbacks as a 20 point road underdog.
(Sep 13) The Kansas Jayhawks beat the Boston College Eagles as a 18.5 point road underdog.
(Oct 19) The Georgia Tech Yellow Jackets beat the Miami Hurricanes as a 18 point road underdog.
(Nov 9) The Nevada Wolf Pack beat the San Diego State Aztecs as a 17 point road underdog.
(Sep 21) The UCLA Bruins beat the Washington State Cougars as a 17 point road underdog.
(Nov 8) The Tulsa Golden Hurricane beat the UCF Knights as a 17.0 point home underdog.
(Oct 12) The UNLV Rebels beat the Vanderbilt Commodores as a 16.5 point road underdog.
(Aug 31) The Wyoming Cowboys beat the Missouri Tigers as a 16.5 point home underdog.
(Nov 9) The Illinois Fighting Illini beat the Michigan State Spartans as a 15.5 point road underdog.
(Sep 14) The Arizona State Sun Devils beat the Michigan State Spartans as a 15.5 point road underdog.
(Oct 31) The Georgia Southern Eagles beat the App State Mountaineers as a 15 point road underdog.
(Nov 16) The West Virginia Mountaineers beat the Kansas State Wildcats as a 14 point road underdog.
(Nov 29) The West Virginia Mountaineers beat the TCU Horned Frogs as a 14 point road underdog.
(Nov 23) The Colorado Buffaloes beat the Washington Huskies as a 14.0 point home underdog.
(Oct 5) The Virginia Tech Hokies beat the Miami Hurricanes as a 14 point road underdog.
(Sep 21) The Buffalo Bulls beat the Temple Owls as a 14.0 point home underdog.
(Sep 7) The California Golden Bears beat the Washington Huskies as a 13.5 point road underdog.
(Oct 26) The Colorado State Rams beat the Fresno State Bulldogs as a 13.5 point road underdog.
(Oct 5) The Stanford Cardinal beat the Washington Huskies as a 13.5 point home underdog.
(Nov 23) The Nevada Wolf Pack beat the Fresno State Bulldogs as a 13.5 point road underdog.
(Nov 23) The Arizona State Sun Devils beat the Oregon Ducks as a 13.0 point home underdog.
(Nov 16) The Rice Owls beat the Middle Tennessee Blue Raiders as a 13 point road underdog.
(Oct 26) The Oklahoma State Cowboys beat the Iowa State Cyclones as a 11.5 point road underdog.
(Aug 30) The Nevada Wolf Pack beat the Purdue Boilermakers as a 11.0 point home underdog.
(Nov 29) The South Alabama Jaguars beat the Arkansas State Red Wolves as a 10.5 point home underdog.
(Oct 26) The Kentucky Wildcats beat the Missouri Tigers as a 10.0 point home underdog.
(Aug 24) The Hawai'i Rainbow Warriors beat the Arizona Wildcats as a 10.0 point home underdog.
(Oct 19) The Oregon State Beavers beat the California Golden Bears as a 10 point road underdog.
(Nov 26) The Northern Illinois Huskies beat the Western Michigan Broncos as a 10.0 point home underdog.
(Aug 29) The Central Arkansas Bears beat the Western Kentucky Hilltoppers as a 10 point road underdog.
(Oct 26) The San José State Spartans beat the Army Black Knights as a 10 point road underdog.
Out of 452 games with spreads of 10 or higher, 39 teams, or 8.63% were able to pull off the outright victory.