(Sep 7) The Northern Illinois Huskies beat the Notre Dame Fighting Irish as a 28.5 point road underdog.
(Oct 23) The Kennesaw State Owls beat the Liberty Flames as a 27.0 point home underdog.
(Oct 5) The Vanderbilt Commodores beat the Alabama Crimson Tide as a 23.5 point home underdog.
(Nov 23) The Georgia State Panthers beat the Texas State Bobcats as a 23 point road underdog.
(Nov 16) The Stanford Cardinal beat the Louisville Cardinals as a 21.0 point home underdog.
(Sep 7) The St. Francis (PA) Red Flash beat the Kent State Golden Flashes as a 17.5 point road underdog.
(Sep 2) The Boston College Eagles beat the Florida State Seminoles as a 16.5 point road underdog.
(Oct 5) The UL Monroe Warhawks beat the James Madison Dukes as a 16.5 point home underdog.
(Oct 4) The Houston Cougars beat the TCU Horned Frogs as a 16.5 point road underdog.
(Sep 28) The Kentucky Wildcats beat the Ole Miss Rebels as a 15 point road underdog.
(Nov 23) The Oklahoma Sooners beat the Alabama Crimson Tide as a 14.0 point home underdog.
(Oct 5) The Arkansas Razorbacks beat the Tennessee Volunteers as a 14.0 point home underdog.
(Nov 2) The Texas Tech Red Raiders beat the Iowa State Cyclones as a 13.5 point road underdog.
(Aug 31) The Vanderbilt Commodores beat the Virginia Tech Hokies as a 13.5 point home underdog.
(Oct 26) The Ball State Cardinals beat the Northern Illinois Huskies as a 13.5 point home underdog.
(Nov 23) The Florida Gators beat the Ole Miss Rebels as a 13.0 point home underdog.
(Sep 21) The Buffalo Bulls beat the Northern Illinois Huskies as a 13 point road underdog.
(Sep 28) The Colorado Buffaloes beat the UCF Knights as a 12.5 point road underdog.
(Nov 2) The Rice Owls beat the Navy Midshipmen as a 12.5 point home underdog.
(Nov 2) The Houston Cougars beat the Kansas State Wildcats as a 12.5 point home underdog.
(Oct 15) The New Mexico State Aggies beat the Louisiana Tech Bulldogs as a 12.5 point home underdog.
(Sep 6) The BYU Cougars beat the SMU Mustangs as a 12.5 point road underdog.
(Oct 12) The Vanderbilt Commodores beat the Kentucky Wildcats as a 12.5 point road underdog.
(Nov 2) The Hawai'i Rainbow Warriors beat the Fresno State Bulldogs as a 12 point road underdog.
(Nov 16) The Louisiana Tech Bulldogs beat the Western Kentucky Hilltoppers as a 11.5 point road underdog.
(Sep 7) The California Golden Bears beat the Auburn Tigers as a 11.5 point road underdog.
(Nov 2) The Louisville Cardinals beat the Clemson Tigers as a 11 point road underdog.
(Sep 28) The Old Dominion Monarchs beat the Bowling Green Falcons as a 11 point road underdog.
(Oct 11) The Northwestern Wildcats beat the Maryland Terrapins as a 11 point road underdog.
(Nov 23) The Oregon State Beavers beat the Washington State Cougars as a 11.0 point home underdog.
(Sep 7) The UL Monroe Warhawks beat the UAB Blazers as a 10.5 point home underdog.
(Oct 19) The Old Dominion Monarchs beat the Texas State Bobcats as a 10.5 point home underdog.
(Sep 14) The Toledo Rockets beat the Mississippi State Bulldogs as a 10.5 point road underdog.
(Oct 12) The Buffalo Bulls beat the Toledo Rockets as a 10.5 point home underdog.
(Nov 16) The New Mexico Lobos beat the Washington State Cougars as a 10.5 point home underdog.
(Nov 16) The Syracuse Orange beat the California Golden Bears as a 10.5 point road underdog.
(Sep 21) The James Madison Dukes beat the North Carolina Tar Heels as a 10 point road underdog.
Out of 381 games with spreads of 10 or higher, 37 teams, or 9.71% were able to pull off the outright victory.