(Sep 26) The Kansas State Wildcats beat the Oklahoma Sooners as a 28 point road underdog.
(Nov 7) The Maryland Terrapins beat the Penn State Nittany Lions as a 27 point road underdog.
(Oct 31) The Michigan State Spartans beat the Michigan Wolverines as a 25 point road underdog.
(Dec 5) The Rice Owls beat the Marshall Thundering Herd as a 24.5 point road underdog.
(Dec 12) The LSU Tigers beat the Florida Gators as a 23 point road underdog.
(Oct 3) The Tulsa Golden Hurricane beat the UCF Knights as a 19.5 point road underdog.
(Dec 5) The New Mexico Lobos beat the Wyoming Cowboys as a 18.0 point home underdog.
(Oct 30) The Maryland Terrapins beat the Minnesota Golden Gophers as a 17.5 point home underdog.
(Nov 21) The Illinois Fighting Illini beat the Nebraska Cornhuskers as a 17 point road underdog.
(Oct 3) The Arkansas Razorbacks beat the Mississippi State Bulldogs as a 16.5 point road underdog.
(Nov 7) The Liberty Flames beat the Virginia Tech Hokies as a 16.5 point road underdog.
(Sep 19) The Liberty Flames beat the Western Kentucky Hilltoppers as a 15.5 point road underdog.
(Sep 12) The Arkansas State Red Wolves beat the Kansas State Wildcats as a 15.5 point road underdog.
(Dec 12) The New Mexico Lobos beat the Fresno State Bulldogs as a 15.0 point home underdog.
(Sep 26) The Mississippi State Bulldogs beat the LSU Tigers as a 14.5 point road underdog.
(Oct 10) The Missouri Tigers beat the LSU Tigers as a 14 point road underdog.
(Oct 3) The NC State Wolfpack beat the Pittsburgh Panthers as a 14 point road underdog.
(Dec 5) The Eastern Michigan Eagles beat the Western Michigan Broncos as a 13.5 point road underdog.
(Nov 28) The Michigan State Spartans beat the Northwestern Wildcats as a 13.5 point home underdog.
(Sep 12) The Georgia Tech Yellow Jackets beat the Florida State Seminoles as a 13.5 point road underdog.
(Oct 17) The Florida State Seminoles beat the North Carolina Tar Heels as a 13.5 point home underdog.
(Nov 27) The Oregon State Beavers beat the Oregon Ducks as a 13.0 point home underdog.
(Sep 3) The South Alabama Jaguars beat the Southern Miss Golden Eagles as a 12.5 point road underdog.
(Dec 5) The Indiana Hoosiers beat the Wisconsin Badgers as a 12.5 point road underdog.
(Nov 28) The Rutgers Scarlet Knights beat the Purdue Boilermakers as a 12 point road underdog.
(Nov 28) The East Carolina Pirates beat the SMU Mustangs as a 12.0 point home underdog.
(Dec 5) The Stanford Cardinal beat the Washington Huskies as a 12 point road underdog.
(Nov 21) The Middle Tennessee Blue Raiders beat the Troy Trojans as a 11.5 point road underdog.
(Sep 12) The Louisiana Ragin' Cajuns beat the Iowa State Cyclones as a 11 point road underdog.
(Oct 3) The TCU Horned Frogs beat the Texas Longhorns as a 10.5 point road underdog.
(Oct 10) The Kansas State Wildcats beat the TCU Horned Frogs as a 10.5 point road underdog.
(Oct 24) The Wake Forest Demon Deacons beat the Virginia Tech Hokies as a 10.5 point home underdog.
(Oct 23) The Jacksonville State Gamecocks beat the Florida International Golden Panthers as a 10.5 point road underdog.
(Dec 5) The Coastal Carolina Chanticleers beat the BYU Cougars as a 10.0 point home underdog.
(Oct 31) The Louisiana Tech Bulldogs beat the UAB Blazers as a 10.0 point home underdog.
(Nov 6) The San José State Spartans beat the San Diego State Aztecs as a 10 point road underdog.
Out of 293 games with spreads of 10 or higher, 36 teams, or 12.29% were able to pull off the outright victory.