A look at 2021's Biggest Upsets.
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(Oct 16)    The UL Monroe Warhawks beat the Liberty Flames as a 32.5 point home underdog.
(Nov 13)    The Kansas Jayhawks beat the Texas Longhorns as a 31 point road underdog.
(Sep 25)    The Bowling Green Falcons beat the Minnesota Golden Gophers as a 30.5 point road underdog.
(Sep 11)    The Duquesne Dukes beat the Ohio Bobcats as a 28.5 point road underdog.
(Sep 11)    The Jacksonville State Gamecocks beat the Florida State Seminoles as a 27.5 point road underdog.
(Sep 18)    The Northern Arizona Lumberjacks beat the Arizona Wildcats as a 26.5 point road underdog.
(Oct 23)    The Illinois Fighting Illini beat the Penn State Nittany Lions as a 24.5 point road underdog.
(Sep 25)    The UL Monroe Warhawks beat the Troy Trojans as a 23.5 point home underdog.
(Oct 23)    The Rice Owls beat the UAB Blazers as a 23.5 point road underdog.
(Sep 4)    The Montana Grizzlies beat the Washington Huskies as a 22.5 point road underdog.
(Sep 2)    The UC Davis Aggies beat the Tulsa Golden Hurricane as a 22 point road underdog.
(Sep 4)    The East Tennessee State Buccaneers beat the Vanderbilt Commodores as a 21 point road underdog.
(Nov 6)    The South Carolina Gamecocks beat the Florida Gators as a 20.5 point home underdog.
(Oct 23)    The New Mexico Lobos beat the Wyoming Cowboys as a 20 point road underdog.
(Sep 4)    The Northern Illinois Huskies beat the Georgia Tech Yellow Jackets as a 19 point road underdog.
(Oct 9)    The Texas A&M Aggies beat the Alabama Crimson Tide as a 18.5 point home underdog.
(Oct 9)    The Florida State Seminoles beat the North Carolina Tar Heels as a 17.5 point road underdog.
(Sep 4)    The Utah State Aggies beat the Washington State Cougars as a 17.5 point road underdog.
(Sep 11)    The Stanford Cardinal beat the USC Trojans as a 17 point road underdog.
(Oct 30)    The Washington State Cougars beat the Arizona State Sun Devils as a 16.5 point road underdog.
(Oct 2)    The Navy Midshipmen beat the UCF Knights as a 15.0 point home underdog.
(Nov 19)    The Southern Miss Golden Eagles beat the Louisiana Tech Bulldogs as a 15 point road underdog.
(Sep 18)    The Colorado State Rams beat the Toledo Rockets as a 14.5 point road underdog.
(Nov 6)    The Illinois Fighting Illini beat the Minnesota Golden Gophers as a 14.5 point road underdog.
(Sep 11)    The Oregon Ducks beat the Ohio State Buckeyes as a 14.5 point road underdog.
(Sep 18)    The Western Michigan Broncos beat the Pittsburgh Panthers as a 14 point road underdog.
(Oct 9)    The Akron Zips beat the Bowling Green Falcons as a 14 point road underdog.
(Oct 30)    The Bowling Green Falcons beat the Buffalo Bulls as a 13.5 point road underdog.
(Oct 23)    The UL Monroe Warhawks beat the South Alabama Jaguars as a 13.5 point home underdog.
(Nov 13)    The Texas Tech Red Raiders beat the Iowa State Cyclones as a 13.0 point home underdog.
(Nov 27)    The Hawai'i Rainbow Warriors beat the Wyoming Cowboys as a 13 point road underdog.
(Oct 9)    The Ball State Cardinals beat the Western Michigan Broncos as a 13 point road underdog.
(Oct 9)    The Northern Illinois Huskies beat the Toledo Rockets as a 13 point road underdog.
(Oct 16)    The LSU Tigers beat the Florida Gators as a 12.5 point home underdog.
(Nov 13)    The Georgia State Panthers beat the Coastal Carolina Chanticleers as a 12.5 point road underdog.
(Nov 6)    The Colorado Buffaloes beat the Oregon State Beavers as a 11.5 point home underdog.
(Oct 2)    The Temple Owls beat the Memphis Tigers as a 11.0 point home underdog.
(Oct 29)    The Navy Midshipmen beat the Tulsa Golden Hurricane as a 11 point road underdog.
(Sep 18)    The East Carolina Pirates beat the Marshall Thundering Herd as a 11 point road underdog.
(Sep 18)    The Fresno State Bulldogs beat the UCLA Bruins as a 11 point road underdog.
(Sep 25)    The Oregon State Beavers beat the USC Trojans as a 11 point road underdog.
(Oct 2)    The Middle Tennessee Blue Raiders beat the Marshall Thundering Herd as a 11.0 point home underdog.
(Oct 16)    The Purdue Boilermakers beat the Iowa Hawkeyes as a 11 point road underdog.
(Sep 25)    The NC State Wolfpack beat the Clemson Tigers as a 10.5 point home underdog.
(Oct 2)    The Ball State Cardinals beat the Army Black Knights as a 10.5 point home underdog.
(Sep 18)    The Incarnate Word Cardinals beat the Texas State Bobcats as a 10.5 point road underdog.
(Oct 2)    The Hawai'i Rainbow Warriors beat the Fresno State Bulldogs as a 10.5 point home underdog.