A look at 2022's Biggest Upsets.
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(Sep 24)    The Middle Tennessee Blue Raiders beat the Miami Hurricanes as a 25.5 point road underdog.
(Nov 26)    The New Mexico State Aggies beat the Liberty Flames as a 24 point road underdog.
(Sep 10)    The Georgia Southern Eagles beat the Nebraska Cornhuskers as a 23.5 point road underdog.
(Oct 1)    The UConn Huskies beat the Fresno State Bulldogs as a 23.5 point home underdog.
(Nov 19)    The South Carolina Gamecocks beat the Tennessee Volunteers as a 22.5 point home underdog.
(Oct 1)    The Georgia Tech Yellow Jackets beat the Pittsburgh Panthers as a 21.5 point road underdog.
(Nov 19)    The Georgia Tech Yellow Jackets beat the North Carolina Tar Heels as a 21.5 point road underdog.
(Sep 17)    The Eastern Michigan Eagles beat the Arizona State Sun Devils as a 20.5 point road underdog.
(Sep 10)    The Marshall Thundering Herd beat the Notre Dame Fighting Irish as a 20.5 point road underdog.
(Sep 17)    The Charlotte 49ers beat the Georgia State Panthers as a 19.5 point road underdog.
(Nov 12)    The Arizona Wildcats beat the UCLA Bruins as a 19.5 point road underdog.
(Oct 8)    The Texas State Bobcats beat the App State Mountaineers as a 19.5 point home underdog.
(Nov 12)    The Boston College Eagles beat the NC State Wolfpack as a 18 point road underdog.
(Sep 10)    The App State Mountaineers beat the Texas A&M Aggies as a 18 point road underdog.
(Sep 10)    The Washington State Cougars beat the Wisconsin Badgers as a 17.5 point road underdog.
(Nov 12)    The Vanderbilt Commodores beat the Kentucky Wildcats as a 17 point road underdog.
(Sep 17)    The Bowling Green Falcons beat the Marshall Thundering Herd as a 17.0 point home underdog.
(Sep 16)    The Wyoming Cowboys beat the Air Force Falcons as a 16.5 point home underdog.
(Oct 15)    The Stanford Cardinal beat the Notre Dame Fighting Irish as a 16.5 point road underdog.
(Nov 5)    The Michigan State Spartans beat the Illinois Fighting Illini as a 16.5 point road underdog.
(Sep 24)    The Navy Midshipmen beat the East Carolina Pirates as a 16.5 point road underdog.
(Sep 23)    The UTEP Miners beat the Boise State Broncos as a 16.0 point home underdog.
(Oct 15)    The Colorado Buffaloes beat the California Golden Bears as a 15.0 point home underdog.
(Oct 1)    The Florida International Golden Panthers beat the New Mexico State Aggies as a 15 point road underdog.
(Oct 29)    The Charlotte 49ers beat the Rice Owls as a 15 point road underdog.
(Nov 5)    The Liberty Flames beat the Arkansas Razorbacks as a 14.5 point road underdog.
(Nov 15)    The Bowling Green Falcons beat the Toledo Rockets as a 14.5 point road underdog.
(Nov 19)    The Navy Midshipmen beat the UCF Knights as a 14.5 point road underdog.
(Nov 19)    The Vanderbilt Commodores beat the Florida Gators as a 14.0 point home underdog.
(Nov 26)    The South Carolina Gamecocks beat the Clemson Tigers as a 14 point road underdog.
(Oct 22)    The Florida International Golden Panthers beat the Charlotte 49ers as a 14 point road underdog.
(Sep 10)    The Kansas Jayhawks beat the West Virginia Mountaineers as a 14 point road underdog.
(Nov 5)    The LSU Tigers beat the Alabama Crimson Tide as a 13.5 point home underdog.
(Oct 1)    The Boston College Eagles beat the Louisville Cardinals as a 13.5 point home underdog.
(Oct 8)    The Arizona State Sun Devils beat the Washington Huskies as a 13.5 point home underdog.
(Sep 10)    The Middle Tennessee Blue Raiders beat the Colorado State Rams as a 13.5 point road underdog.
(Sep 17)    The Southern Illinois Salukis beat the Northwestern Wildcats as a 13.5 point road underdog.
(Sep 17)    The Tulane Green Wave beat the Kansas State Wildcats as a 13.5 point road underdog.
(Sep 24)    The Kansas State Wildcats beat the Oklahoma Sooners as a 13.5 point road underdog.
(Nov 12)    The UL Monroe Warhawks beat the Georgia State Panthers as a 13.5 point road underdog.
(Nov 12)    The UConn Huskies beat the Liberty Flames as a 13.5 point home underdog.
(Oct 15)    The Georgia Southern Eagles beat the James Madison Dukes as a 13.0 point home underdog.
(Sep 3)    The Delaware Blue Hens beat the Navy Midshipmen as a 13 point road underdog.
(Nov 26)    The Tulsa Golden Hurricane beat the Houston Cougars as a 13 point road underdog.
(Sep 24)    The Southern Miss Golden Eagles beat the Tulane Green Wave as a 12 point road underdog.
(Nov 12)    The Washington Huskies beat the Oregon Ducks as a 12 point road underdog.
(Nov 19)    The Indiana Hoosiers beat the Michigan State Spartans as a 12 point road underdog.
(Oct 8)    The Utah State Aggies beat the Air Force Falcons as a 11.5 point home underdog.
(Sep 17)    The Rice Owls beat the Louisiana Ragin' Cajuns as a 11.5 point home underdog.
(Nov 19)    The Hawai'i Rainbow Warriors beat the UNLV Rebels as a 11.0 point home underdog.
(Oct 15)    The Old Dominion Monarchs beat the Coastal Carolina Chanticleers as a 11 point road underdog.
(Nov 19)    The Virginia Tech Hokies beat the Liberty Flames as a 10.5 point road underdog.
(Oct 1)    The Rice Owls beat the UAB Blazers as a 10.5 point home underdog.
(Oct 12)    The Louisiana Ragin' Cajuns beat the Marshall Thundering Herd as a 10.5 point road underdog.
(Nov 25)    The Nebraska Cornhuskers beat the Iowa Hawkeyes as a 10.5 point road underdog.
(Nov 26)    The Texas A&M Aggies beat the LSU Tigers as a 10.0 point home underdog.
(Oct 22)    The Duke Blue Devils beat the Miami Hurricanes as a 10 point road underdog.
(Sep 10)    The Duke Blue Devils beat the Northwestern Wildcats as a 10 point road underdog.
(Oct 29)    The North Texas Mean Green beat the Western Kentucky Hilltoppers as a 10 point road underdog.
(Nov 16)    The Western Michigan Broncos beat the Central Michigan Chippewas as a 10 point road underdog.